Oncology

Our Expertise in Oncology and Cancer Models

We offer a wide range of preclinical oncology models and tumor modeling in vivo for the study of cancer growth and metastasis in mice and rats.

The two most used models in oncology R&D for the assessment of potential efficacy of tested technology are the xenograft and the orthotopic model. We combine these in vivo models with in vitro and ex vivo analyses, such as FACS, angiogenesis and cell invasion assays (i.e. HET-CAM assay), and with high-level histological evaluation and imaging tools (Laser Doppler, MRI, X-ray).

  • Subcutaneous Xenograft Models for a variety of human cancers:
    • Pancreatic adenocarcinoma
    • Breast cancer
    • Prostate cancer
    • Melanoma
    • Glioblastoma
    • Neuroblastoma
    • Colorectal carcinoma
    • Liver cancer
    • Lung cancer
    • Lymphoid cancer
  • Orthotopic implantation:
    • Orthotopic pancreatic cancer model
    • Intra-parenchimal glioblastoma model
  • Metastatic models (i.e. Lewis Lung Adenocarcinoma systemic administration)
  • Hollow fiber assay
  • Complementary models:
    • In vitro screening for cytotoxicity activity
    • In vitro screening for anti-angiogenic activity (Endothealial Tube Formation assay in HUVEC, Aortic Ring Assay)
    • Ex ovo HET-CAM assay
  • Histological evaluation and imaging capabilities

 

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