CNS

Our Expertise in CNS pathologies

CNS-pharmaseed-europe

We offer extensive CNS disease know-how and research services, allowing a complete investigation of pharmacokinetics and pharmacodynamics of a drug in vivo, as well as within a set of behavioural and analytical tests. We developed and offer CNS models for:

  • Parkinson’s disease (6-hydroxydopamine, MPTP)
  • Alzheimer’s disease
  • Vascular dementia
  • Hippocampal neurodegeneration (Kainic acid)
  • Epilepsy (Pilocarpine, Kainic acid, Pentylenetetrazol (PTZ))
  • Spinal cord and traumatic brain injuries (Close/Open head)
  • Ototoxicity (cisplatin)
  • Itch model (Substance P/ capsaicin)
  • Complementary ex-vivo models – organotypic brain slices
  • Schizophrenia (Amphetamine, Ketamine, Apomorphine, PCP)
  • PTSD (corticosterone)
  • Autism (Poly IC)
  • Depression testing (Force swimming, Tail suspension)
  • Anxiety testing (open field, elevated maze)
  • Neuropathic pain (spinal nerve ligation, sciatic nerve ligation, sciatic nerve inflammation)
  • Acute pain (post-operative pain, formalin/capsaicin test)
  • Chronic/inflammatory pain (CFA/Carrageenan)
  • Aged mice (motor and cognition testing: Elevated Maze, Nose Poke, Object Recognition, Social Recognition)
  • Complementary ex vivo models for neurodegenerative diseases, such as organotypic brain slices.

  • Categories:
    CNS

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